EAS L-Glutamine
Anti-Catabolic Amino Acid
Supplement Highlights:
• Prevent Muscle Cell Breakdown
• Improve Nitrogen Retention and Protein Synthesis
• Increase Muscle Cell Volume
Description:
L-Glutamine 1000 grams from EAS.
L-Glutamine is the most abundant free amino acid in muscle tissue, and it plays a principal role in protein metabolism, cell volumizing, and anti-catabolism. EAS' L-Glutamine powder is tasteless and odorless and dissolves quickly and easily in water. It can be added to your favorite protein-containing drink to enhance dietary intake of this conditionally essential nutrient.
Q: What is L-Glutamine?
A: L-Glutamine is the most abundant free amino acid in muscle tissue. It is a nonessential amino acid that can be produced by the body under normal conditions. However, under periods of stress, such as intense workouts, the body may have an increased demand making it a conditionally essential amino acid. Supplementation with L-Glutamine may be an effective way to support sufficient glutamine levels, which may aid in recovery and recuperation.
Q: What is the recommended use for L-Glutamine?
A: Here's one suggestion. During periods of high-intensity exercise or increased stress to the body, try 2 to 4 grams (1/2-1 tsp) 2 to 3 times daily. Taking L-Glutamine after workouts or before bedtime, times when muscle tissue typically undergoes repair and recuperation, could be particularly effective.
What's in it?
Serving size 1 teaspoon (4g)
Amount Per Serving:
L-Glutamine 4 g
Suggested use:
As a dietary supplement, take 2 to 4 grams (½ to 1 teaspoon) 2 to 3 times daily.
L-Glutamine
Every once in a while you hear of something new in the bodybuilding supplement category or get introduced to a new nutritional supplement, but don't really get that interested since there is so much hype for even the most mediocre supplements and there are so many products to choose from you just can't afford to take them all. Well take a minute to read this brief overview of L-Glutamine and then take another to get yourself a good supply and start taking this stuff right away. L-Glutamine
just may be the most important amino acid you every whipped out your GNC Gold Card for. It been used in hospitals for years to speed recovery and improve the maintenance of muscle mass, but only recently has the bodybuilding community embraced it. With more an more scientific evaluation being done on glutamine and athletes you will soon understand why L-Glutamine is so very important to those athletes trying to maintain that lean and hard look.
What is it?
L-Glutamine is the most abundant amino acid in the body. Despite the large number of enzymatic reactions that could cause it's depletion, it has the highest concentration in the plasma (0.5 to 0.9 mmol/L) and except for taurine, it constitutes more than 50% of free intracellular amino acid pool" Glutamine is not an essential amino acid as it can be made from the amino acid glutamic acid.
What Does It Do?
"Glutamine acts as a precursor in the synthesis of nucleotides such as adenosine triphosphate (ATP), purines, pyrimidines, and other amino acids. It is avidly consumed by rapidly dividing cells such as enterocytes, malignant cells, fibroblasts, and reticulocytes. The small intestine and the kidney have been shown to be major sites for glutamine utilization in many species under normal and acidotic conditions. Glutamine serves as a major fuel for many cells including enterocytes (small
intestine), reticulocytes and stimulated lymphocytes (immune system cells). Research has shown that these cells not only depend on glutamine for normal metabolism, but when glutamine is not available in sufficient amounts, these tissues atrophy or malfunction."
Why Supplement Glutamine?
Increases Intra-muscular Stores of Glutamine
Since skeletal muscle supplies the majority of glutamine, increased utilization by other tissues, as occurs in response to starvation, exercise trauma, or infection affects skeletal muscle metabolism. Increases glutamine utilization results in a decrease in muscle protein synthesis and eventually, an increase in muscle protein degradation as glutamine continues to be consumed. Glutamine supplementation has been shown to promote muscle glycogen accumulation by mechanisms possibly including
diversion of glutamine carbon to glycogen.
Decreases Degradation of Muscle Protein
Due to the extreme popularity of glutamine to other cells in the body supplemental glutamine acts to prevent the catabolism of muscle protein by providing free glutamine for utilization during increased needs.
Increases Muscle Protein Synthesis
Glutamine has been positively linked to increased protein synthesis by establishing a positive intra-muscular glutamine pool. This works by sparing the muscle tissue form being catabolized in order to provide glutamine for other cells in the body, therefore allowing the muscle tissue to use glutamine to synthesize new protein tissue.
Increases Cell Volume
Cellular hydration state is has a major influence on cell function. Glutamine has been shown to increase cell volume. Interestingly enough insulin and glutamine together seem to work even better at volumizing the cell. Cell swelling has also shown to promote glycogen synthesis in liver and muscle tissue.
It has been suggested that after exercise the availability of glutamine promotes muscle glycogen accumulation by mechanisms possibly including diversion of glutamine carbon skeleton to glycogen.
Increases Immune Function
An additional consequence to chronically depleted glutamine levels is immuno-suppression. Success in any athletic endeavor depends on the ability to maintain rigorous training. Frequent illness due to immuno-suppression may result in the loss of training time and decreased performance. Glutamine Supplementation may help prevent this occurring.
Maintains Acid-Base Balance
By increasing plasma bicarbonate concentration glutamine may be beneficial in regulating acid -base balance. This could be very beneficial for athlete that could use help buffering lactic acid during high multiple sets of high intensity exercise.
Increases Growth Hormone
Glutamine supplementation as small as 2 grams has been shown to increases plasma growth hormone levels. Growth hormone has been shown to help shift the fuel for muscle from glucose to fatty acids. Growth hormone has also been proposed to play a major role in acid base balance.
How Much Should You Take?
The suggested supplemented amount would fall between 8-20 grams per day depending on your dietary intake, health, and level or intensity and frequency of exercise. It seems logical that supplementing 2-5 grams 2-4 times per day since smaller more frequent dosages would elicit a positive response without stimulating the excretion of glutamine as has been shown to occur in large single dosages due to liver glutamine removal.
References
Bulus, N., et. al.; Physiological Importance of Glutamine. Metabolism Vol. 38, No. 8, Suppl 1 August, 1989: pp 1-5.
Varnier, M., et. al., Stimulatory effect of Glutamine on glycogen accumulation in human skeleton muscle. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E302-E315, 1995.
MacLennan, P.A., et. al.; A positive relationship between protein synthetic rate and intracellular glutamine concentration in purfused rat skeletal muscle. FEB Vol. 215, No. 1, 187-191, 1987.
Millward, D.J., et.al.; Muscle glutamine concentration and protein turnover in vivo in malnutrition and in endotoxemia. Metabolism, 38(suppl-1):6-13, 1989
Rennie M.J., et. al.; Glutamine Metabolism and Transport in Skeletal Muscle and Heart and Their Clinical Relevance. J. Nutr. 126: 1142S-1149S, 1996.
Welbourne, T.C., Increased Plasma Bicarbonate and Growth Hormone After and Oral Glutamine Load. Am J Clin Nutr 1995; 61:1058-1061.
Lavoinne, A., et. al.; Stimulation of glycogen synthesis and lipogenesis by glutamine in isolated rat adipocytes. Biochemical journal, 248:429-437, 1987.
Parry-Billings, M., et. al.; Effects of changes in cell volume on the rates of glutamine and alanine release from rat skeletal muscle in vitro. Biochemical Journal, 276:559-561, 1991.
Hartmann, F., et. al.; Intestinal glutamine metabolism. Meta
